Assessing the effects of the antidepressant venlafaxine to Fathead minnows exposed to environmentally relevant concentrations over a full life cycle

Venlafaxine is an antidepressant and anti-anxiety drug that has been detected in municipal wastewater at low concentrations. To assess the potential of this compound to affect the survival, development and reproductive capacity of fish, we exposed Fathead minnow (Pimephales promelas) over a full lifecycle in a flow-through system to nominal venlafaxine concentrations. During the 167–168 day exposure, no significant changes were observed in survival, or the weights and lengths of Fathead minnows. At maturity, there were no significant differences relative to controls in condition factor, liver-somatic index, or secondary sex characteristics in the venlafaxine exposed male or female fish. Venlafaxine exposure at environmentally relevant concentrations caused no adverse effects in Fathead minnows. This study is the first to assess the potential for effects in fish exposed to the antidepressant venlafaxine over a full lifecycle.

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Metadata Record Information

File Identifier
c7db75f4-45b5-4594-91cc-97ede8e61a73 XML
Date Stamp
2024-06-06T18:55:56.878Z
Metadata language

eng; CAN
Character set
UTF8
Hierarchy Level
Dataset
Point of contact
  Government of Canada; Environment and Climate Change Canada; Science and Technology Branch / Water Science and Technology / Aquatic Contaminants Research Division - ACRD Data Management Team
867 Lakeshore Rd. , Burlington , Ontario , L7S 1A1 , Canada
 

Data identification

Date (Publication)
2018-05-04
Date (Creation)
2018-05-04
Status
Completed
Metadata language

eng; CAN
Character set
UTF8
Topic category
  • Environment
  • Biota
Maintenance and Update Frequency
Not planned
Spatial representation type
Text, table
Principal investigator
  Government of Canada; Environment and Climate Change Canada; Science and Technology Branch / Water Science and Technology / Aquatic Contaminants Research Division - Dr. Joanne Parrott ( Research scientist )
867 Lakeshore Rd. , Burlington , Ontario , L7S 1A1 , Canada

Keywords

Theme

  • Venlafaxine, Pharmaceutical chemicals

  • Observation/Measurement

  • Fathead minnow (Pimephales promelas)

  • life cycle

  • antidepressant

  • Chemicals Management Plan (CMP)

  • Contaminants

Government of Canada Core Subject Thesaurus

  • Biochemicals

ECCC Information Category EN

  • Nature and Biodiversity - Contaminants

Business Functions

  • Monitor / Assess Substance and Waste Levels in Air, Water, Soil, Biota

  • Assess Toxicity, Manage and Monitor for Environmental Presence of Hazardous Substances and Waste

Branch

  • Science and Technology Branch

Directorate

  • Water Science and Technology

Program (PAA)

  • 1.2.1. Water Quality and Aquatic Ecosystems Health

GC Security Level

  • Unclassified

Geography

  • Ontario (ON)
 
Use Limitation

Open Government Licence - Canada ( http://open.canada.ca/en/open-government-licence-canada )

Access Constraints
License
Use Constraints
License
Begin Date
2015-01-01
End Date
2016-12-30

Extent

N
S
E
W
thumbnail


 
 

Ref. system Reference Systems

Reference system identifier
https://epsg.io / EPSG:4326 /
 

Distribution

Distribution Formats

Distribution format
  • CSV ( 1 )

 
Distributor
  Government of Canada; Environment and Climate Change Canada - Public inquiries centre
Fontaine Building 12th floor, 200 Sacré-Coeur Blvd. , Gatineau , Quebec , K1A 0H3 , Canada
1-800-668-6767
https://www.canada.ca
 
 

Overviews

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W
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Keywords

Chemicals Management Plan (CMP) Contaminants Fathead minnow (Pimephales promelas) Observation/Measurement Venlafaxine, Pharmaceutical chemicals antidepressant life cycle
Branch
Science and Technology Branch
Business Functions
Assess Toxicity, Manage and Monitor for Environmental Presence of Hazardous Substances and Waste Monitor / Assess Substance and Waste Levels in Air, Water, Soil, Biota
Directorate
Water Science and Technology
ECCC Information Category EN
Nature and Biodiversity - Contaminants
GC Security Level
Unclassified
Government of Canada Core Subject Thesaurus
Biochemicals
Program (PAA)
1.2.1. Water Quality and Aquatic Ecosystems Health

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