Metformin: Environmental fate and effects on the fathead minnow (Pimephales promelas)

This study aimed to address the toxicological effects the type-2 diabetes drug, metformin has on wild fathead minnows (Pimephales promelas). Fathead minnow embryos and adults were exposed to metformin via in-lake mesocosm and their survival, development and growth was assessed. Exposures were conducted at Lake 114 located at the International Institute for Sustainable Development-Experimental Lakes Area (IILSD-ELA) in northern Ontario, Canada. Adults were exposed for 56 days to three concentrations of metformin (0, 4, and 40 micrograms per liter (ug/L)) each with four replicates. Fish behavior and mortality was observed daily during the exposure period. After 56 days, fish were captured, dissected and assessed for various health endpoints. Additionally, blood, brain and tissue samples were collected for metabolic endpoints. Additionally, wild fathead minnow eggs spawned in the lake were collected in glass mason jars and transported back to the on site laboratory. One fertilized egg was placed in each well for a total of 20 eggs per plate (thus 20 eggs per replicate for the 3 replicates for a total of 60 eggs per mesocosm and a total of 240 eggs per treatment). Hatching time, measurements, survival and deformities were observed.

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Metadata Record Information

File Identifier
a1e00e1f-b0de-4d31-893d-79f1004b904c XML
Date Stamp
2023-11-29T20:26:41
Metadata language

eng; CAN
Character set
UTF8
Hierarchy Level
Dataset
Point of contact
  Government of Canada; Environment and Climate Change Canada; Science and Technology Branch / Water Science and Technology / Aquatic Contaminants Research Division - ACRD Data Management Team

867 Lakeshore Rd., Burlington, Ontario, L7S 1A1, Canada
 

Data identification

Title

Metformin: Environmental fate and effects on the fathead minnow (Pimephales promelas)
Date (Creation)
2022-05-22
Date (Publication)
2023-08-11
Status
On going
Metadata language

eng; CAN
Character set
utf8
Topic category
  • Environment
Maintenance and Update Frequency
As needed
Principal investigator
  Government of Canada; Environment and Climate Change Canada; Science and Technology Branch / Water Science and Technology / Aquatic Contaminants Research Division - Dr. Erin Ussery ( Research scientist)

867 Lakeshore Rd., Burlington, Ontario, L7S 1A1, Canada
Collaborator
  Government of Canada; Environment and Climate Change Canada; Science and Technology Branch / Water Science and Technology / Aquatic Contaminants Research Division - Dr. Mark McMaster ( Research scientist)

867 Lakeshore Rd., Burlington, Ontario, L7S 1A1, Canada
Collaborator
  Government of Canada; Environment and Climate Change Canada; Science and Technology Branch / Water Science and Technology / Aquatic Contaminants Research Division - Dr. Joanne Parrott ( Research scientist)

867 Lakeshore Rd., Burlington, Ontario, L7S 1A1, Canada
Collaborator
  Government of Canada; Environment and Climate Change Canada; Science and Technology Branch / Water Science and Technology / Aquatic Contaminants Research Division - Dr. Richard Frank ( Research scientist)

867 Lakeshore Rd., Burlington, Ontario, L7S 1A1, Canada
Collaborator
  Government of Canada; Environment and Climate Change Canada; Science and Technology Branch / Water Science and Technology / Aquatic Contaminants Research Division - Dr. Mehran Alaee ( Research scientist)

Keywords

Theme

  • metformin

  • fathead minnow (Pimephales promelas)

  • ecotoxicology

  • pharmaceuticals

  • freshwater

  • Chemicals Management Plan (CMP) of Health Canada

  • New Substances Assessment and Control Bureau (NSACB)

  • life stages

Government of Canada Core Subject Thesaurus

  • Environment

  • Water

Business Functions

  • Assess Toxicity of Substance

  • Assess Toxicity, Manage and Monitor for Environmental Presence of Hazardous Substances and Waste

Branch

  • Science and Technology Branch

Directorate

  • Water Science and Technology

Environment Canada - Program

  • 1.2.1. Water Quality and Aquatic Ecosystems Health

GC Security Level

  • Unclassified

Canada/US States and Provinces

  • Ontario
 
Use Limitation

Open Government Licence - Canada ( http://open.canada.ca/en/open-government-licence-canada)

Access Constraints
License
Use Constraints
License
Begin Date
2019-05-22
End Date
2019-07-23

Extent

N
S
E
W
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Ref. system Reference Systems

Reference system identifier
https://epsg.io / EPSG:4326 /
 

Distribution

Distribution Formats

Distribution format
  • CSV ( Unknown)

 
Distributor
  Government of Canada; Environment and Climate Change Canada - Public inquiries centre

Gatineau, Quebec, K1A 0H3, Canada
1-800-668-6767

 
 

Overviews

N
S
E
W
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Keywords

Chemicals Management Plan (CMP) of Health Canada New Substances Assessment and Control Bureau (NSACB) ecotoxicology fathead minnow (Pimephales promelas) freshwater life stages metformin pharmaceuticals
Branch

Science and Technology Branch
Business Functions

Assess Toxicity of Substance Assess Toxicity, Manage and Monitor for Environmental Presence of Hazardous Substances and Waste
Canada/US States and Provinces

Ontario
Directorate

Water Science and Technology
Environment Canada - Program

1.2.1. Water Quality and Aquatic Ecosystems Health
GC Security Level

Unclassified
Government of Canada Core Subject Thesaurus

Environment Water


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