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                <gmd:LocalisedCharacterString locale="#fra">Évaluation des activités œstrogéniques et perturbatrices des hormones thyroïdiennes de substances d’intérêt prioritaire ciblées en vertu du PGPC3 : benzotriazole, thiocarbamate, phénol à empêchement stérique et un ignifugeant organophosphaté bromé.</gmd:LocalisedCharacterString>
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        <gco:CharacterString>The transition from tadpole to frog (metamorphosis) and gender differentiation are tightly controlled by the endocrine systems and hormones, where exposure to even low concentrations of certain environmental contaminants can change normal hormone processes that have severe effects on biological development and thus the production of healthy, reproductively capable individuals. We will assess the effects of potential endocrine disrupting CMP3 priority substances, where tadpoles are exposed to environmentally relevant concentrations in water or sediment and assessed for effects on time to metamorphosis, growth, gender, expression of genes involved in development and sexual differentiation and histology of thyroid and gonadal tissue.</gco:CharacterString>
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            <gmd:LocalisedCharacterString locale="#fra">La transition du têtard à la grenouille (métamorphose) et la différenciation du sexe sont étroitement contrôlés par les systèmes endocriniens et les hormones, et l’exposition à des concentrations, même faibles, de certains contaminants environnementaux peut perturber les processus hormonaux normaux et engendrer de graves effets sur le développement biologique et, ainsi, sur la production d’individus sains capables de se reproduire. Nous évaluerons les effets de substances d’intérêt prioritaire en vertu du PGPC3 qui causent potentiellement des perturbations endocriniennes au moment où les têtards sont exposés à des concentrations dans l’eau et dans les sédiments pertinentes sur le plan environnemental, et nous évaluerons les effets sur le moment de la métamorphose, la croissance, le sexe, l’expression des gènes telle que reliée au développement ainsi que la différentiation sexuelle et l’histologie des tissus thyroïdiens et gonadiques.</gmd:LocalisedCharacterString>
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