Toxicity of the pharmaceuticals finasteride and melengestrol acetate to benthic invertebrates

The toxicity of pharmaceuticals finasteride (FIN) and melengestrol acetate (MGA) was assessed in freshwater mussels, including acute (48 h) aqueous tests with glochidia from Lampsilis siliquoidea, a sub-chronic (14 days) sediment test with gravid Lampsilis fasciola, chronic (28 days) sediment tests with juvenile L. siliquoidea, and in chronic (42 days) sediment tests with the amphipod Hyalella azteca and the mayfly Hexagenia spp. Testing with mussels assessed survival (glochidia, juvenile mussels), burial ability (juvenile mussels), and filtering and luring behaviour, and viability of brooding glochidia (gravid mussels). Testing with amphipods assessed survival, growth, reproduction and sex ratio. Testing with mayflies assessed survival and growth. Based on the limited number of measured environmental concentrations of both chemicals, and their projected concentrations, no direct effects are expected by these compounds individually on the invertebrates tested. However, organisms are exposed to contaminant mixtures in the aquatic environment, and thus, the effects of FIN and MGA as components of these mixtures require further investigation.

Results were published in a scientific article that can be found here: https://doi.org/10.1007/s11356-020-10121-7

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Metadata Record Information

File Identifier
3765f96e-f4e6-4335-8ea5-adfc7d45ce57 XML
Date Stamp
2022-11-09T17:24:23
Metadata language

eng; CAN
Character set
UTF8
Hierarchy Level
Dataset
Point of contact
  Government of Canada; Environment and Climate Change Canada; Science and Technology Branch / Water Science and Technology / Aquatic Contaminants Research Division - ACRD Data Management Team

867 Lakeshore Rd., Burlington, Ontario, L7S 1A1, Canada
 

Data identification

Title

Toxicity of the pharmaceuticals finasteride and melengestrol acetate to benthic invertebrates
Date (Publication)
2021-10-18
Date (Creation)
2016-01-16
Status
Completed
Metadata language

eng; CAN
Character set
utf8
Topic category
  • Environment
  • Biota
Maintenance and Update Frequency
Not planned
Principal investigator
  Government of Canada; Environment and Climate Change Canada; Science and Technology Branch / Water Science and Technology / Aquatic Contaminants Research Division - Dr. Ève Gilroy ( Research scientist)

867 Lakeshore Rd., Burlington, Ontario, L7S 1A1, Canada
Collaborator
  Government of Canada; Environment and Climate Change Canada; Science and Technology Branch / Water Science and Technology / Aquatic Contaminants Research Division - Dr. Adrienne Bartlett ( Research scientist)

867 Lakeshore Rd., Burlington, Ontario, L7S 1A1, Canada
Collaborator
  Government of Canada; Environment and Climate Change Canada; Science and Technology Branch / Water Science and Technology / Aquatic Contaminants Research Division - Dr. Patty Gillis ( Research scientist)

867 Lakeshore Rd., Burlington, Ontario, L7S 1A1, Canada
Collaborator
  Government of Canada; Environment and Climate Change Canada; Science and Technology Branch / Wildlife and Landscape Science Directorate / Wildlife Toxicology Research Division - Shane de Solla ( Ecotoxicologist)

867 Lakeshore Rd., Burlington, Ontario, L7S 1A1, Canada

Keywords

Theme

  • Freshwater mussel (Lampsilis siliquoidea)

  • Amphipod (Hyalella azteca)

  • Freshwater mussel (Lampsilis fasciola),

  • Mayfly (Hexagenia spp.)

  • Sediment

  • Toxicity

  • Pharmaceuticals

  • Finasteride

  • Melengestrol acetate

  • The New Substances Assessment and Control Bureau (NSACB)

Government of Canada Core Subject Thesaurus

  • Environment

Branch

  • Science and Technology Branch

Program (PAA)

  • 1.2.1. Water Quality and Aquatic Ecosystems Health

Environment Canada - GC Security Classification

  • Unclassified

Directorate

  • Water Science and Technology
 
Use Limitation

Open Government Licence - Canada ( http://open.canada.ca/en/open-government-licence-canada)

Access Constraints
License
Use Constraints
License
Begin Date
2015-01-01
End Date
2016-11-01

Extent

N
S
E
W
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Ref. system Reference Systems

Reference system identifier
/ EPSG:4326 /
 

Distribution

Distribution Formats

Distribution format
  • CSV ( unknown)

 
Distributor
  Government of Canada; Environment and Climate Change Canada - Public Inquiries Centre

Fontaine Building 12th floor, 200 Sacré-Coeur Blvd., Gatineau, Quebec, K1A 0H3, Canada
1-800-668-6767

https://www.canada.ca
 
 

Overviews

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E
W
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Keywords

Amphipod (Hyalella azteca) Finasteride Freshwater mussel (Lampsilis fasciola), Freshwater mussel (Lampsilis siliquoidea) Mayfly (Hexagenia spp.) Melengestrol acetate Pharmaceuticals Sediment The New Substances Assessment and Control Bureau (NSACB) Toxicity
Branch

Science and Technology Branch
Directorate

Water Science and Technology
Environment Canada - GC Security Classification

Unclassified
Government of Canada Core Subject Thesaurus

Environment
Program (PAA)

1.2.1. Water Quality and Aquatic Ecosystems Health


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