Toxicity of the pharmaceuticals finasteride and melengestrol acetate to benthic invertebrates
The toxicity of pharmaceuticals finasteride (FIN) and melengestrol acetate (MGA) was assessed in freshwater mussels, including acute (48 h) aqueous tests with glochidia from Lampsilis siliquoidea, a sub-chronic (14 days) sediment test with gravid Lampsilis fasciola, chronic (28 days) sediment tests with juvenile L. siliquoidea, and in chronic (42 days) sediment tests with the amphipod Hyalella azteca and the mayfly Hexagenia spp. Testing with mussels assessed survival (glochidia, juvenile mussels), burial ability (juvenile mussels), and filtering and luring behaviour, and viability of brooding glochidia (gravid mussels). Testing with amphipods assessed survival, growth, reproduction and sex ratio. Testing with mayflies assessed survival and growth. Based on the limited number of measured environmental concentrations of both chemicals, and their projected concentrations, no direct effects are expected by these compounds individually on the invertebrates tested. However, organisms are exposed to contaminant mixtures in the aquatic environment, and thus, the effects of FIN and MGA as components of these mixtures require further investigation.
Results were published in a scientific article that can be found here: https://doi.org/10.1007/s11356-020-10121-7
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Metadata Record Information
- File Identifier
- 3765f96e-f4e6-4335-8ea5-adfc7d45ce57 XML
- Date Stamp
- 2022-11-09T17:24:23
- Metadata language
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eng; CAN
- Character set
- UTF8
- Hierarchy Level
- Dataset
Data identification
- Date (Publication)
- 2021-10-18
- Date (Creation)
- 2016-01-16
- Status
- Completed
- Metadata language
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eng; CAN
- Character set
- utf8
- Topic category
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- Environment
- Biota
- Maintenance and Update Frequency
- Not planned
Keywords
- Theme
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Freshwater mussel (Lampsilis siliquoidea)
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Amphipod (Hyalella azteca)
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Freshwater mussel (Lampsilis fasciola),
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Mayfly (Hexagenia spp.)
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Sediment
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Toxicity
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Pharmaceuticals
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Finasteride
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Melengestrol acetate
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The New Substances Assessment and Control Bureau (NSACB)
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Government of Canada Core Subject Thesaurus
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Environment
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Branch
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Science and Technology Branch
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Program (PAA)
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1.2.1. Water Quality and Aquatic Ecosystems Health
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Environment Canada - GC Security Classification
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Unclassified
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Directorate
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Water Science and Technology
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- Use Limitation
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Open Government Licence - Canada ( http://open.canada.ca/en/open-government-licence-canada )
- Access Constraints
- License
- Use Constraints
- License
- Begin Date
- 2015-01-01
- End Date
- 2016-11-01
Extent
Ref. system Reference Systems
- Reference system identifier
- / EPSG:4326 /
Distribution
Distribution Formats
- Distribution format
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CSV
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unknown
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CSV
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unknown
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https://www.canada.ca